EUROGESIC

Pharmacological Properties:
Naproxen sodium is a non-steroidal, non-narcotic anti-inflammatory analgesic with marked antipyretic properties. Naproxen is not a CNS depressant and does not induce enzymatic metabolism. It is quickly and completely absorbed from the intestine after oral administration.
Indications:
As analgesic and anti-inflammatory in acute and chronic, painful and inflammatory processes of soft tissues and skeletal muscle. As analgesic and anti-inflammatory for bursitis, tendinitis, synovitis, tenosynovitis and lumbago. For analgesic action after dislocation, sprain, orthopedic manipulations, surgery and dental extraction. For uterine relaxation and post delivery analgesic for the mother who does not breastfeed. As analgesic in dysmenorrhea and after IUD insertion. As anti-inflammatory and analgesic drug in rheumatoid arthritis, osteoarthritis (degenerative arthritis), ankylosing spondylitis and gout.
Dosage and Administration:
Adults: 2 tablets of 275 mg as starting dose then 1 tablet every 6 to 8 hours. Children: Over 6 years of age 1 tablet of 100 mg or 4 ml suspension every 8 hours. Under 6 years of age, 1 pediatric suppository or 2 ml suspension every 8 hours. Juvenile rheumatoid arthritis: 10 mg/kg/day divided every 12 hours.
Contraindications:
Pregnancy, breastfeeding and in cases of hypersensitivity to acetylsalicylic acid or other NSAID (possibility of crossed hypersensitivity).
Precautions and Warnings:
As EUROGESIC has high protein binding properties, it may displace other drugs from protein binding sites; therefore, caution should be taken when co-administering with anticoagulants, hydantoins, warfarin, oral hypoglicemiant drugs, etc. Administer under medical supervision to patients with renal, hepatic or heart failure; in patients with gastrointestinal disease.
Adverse Reactions:
It may interfere with platelet aggregation, epigastric pain, nausea, abdominal discomfort, headache, vertigo.
Interactions:
Due to its high protein-binding properties, the concomitant use with hydantoin must be monitored. Caution should be taken when administered concomitantly with beta-blockers such as propanolol, probenecid and methotrexate. Caution is recommended with use of anticoagulants and sulphonylurea.
On-dosages:
A significant over dose may cause dizziness, indigestion, nausea and vomiting.
Storage:
Store at a temperature not exceeding 30°C . Away from light and moist (tablets). Store at a temperature not exceeding 25°C. Away from light. Do not refrigerate (suspension and suppositories).